Table 1.
Pharmacokinetics of tau mAb blood-brain barrier penetrance. ELISA assays of DMR7 and SKT82 levels in CSF and plasma of mice 4- and 7-days post-IP injection quantified in comparison to standard curves of purified DMR7 and SKT82
| Dose (mg/kg) | Days post injection | Plasma (μM) | Plasma %CV |
CSF (nM) | CSF %CV |
CSF/ plasma ratio (%) | |
|---|---|---|---|---|---|---|---|
|
DMR7 n = 3 |
60 | 4 | 1.29 + 0.22 | 17 | 3.78 + 0.95 | 25 | 0.31 + 0.12 |
|
DMR7 n = 3 |
60 | 7 | 1.24 + 0.45 | 36 | 2.9 + 1.9 | 66 | 0.22 + 0.08 |
|
SKT82 n = 2 |
60 | 4 | 0.91 + 0.24 | 26 | 1.20 + 0.06 | 5 | 0.14 + 0.03 |
|
SKT82 n = 3 |
60 | 7 | 0.65 + 0.19 | 30 | 0.70 + 0.16 | 28 | 0.12 + 0.06 |