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. 2020 Nov 5;11:61. doi: 10.1186/s13293-020-00335-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Sub-classification of fibroblast cells identified sub-cell types. a Five sub-cell types of heart fibroblast cells were identified by unsupervised clustering. Most female cells formed cluster 0 and 1 while most male cells formed cluster 2 and 3. b Distribution of male/female cells in each cluster. Cluster 0, 1, 2, and 3 exhibited dominance of one sex, while cluster 4 was a mixture of both sexes. c Expression of top ten marker genes distinguishing each cluster from the other clusters indicated strong sub-cell type specificity. Nonetheless, expression patterns were perceptually more similar between cluster 0 and 2 as well as those between cluster 1 and 3, than other pairs of clusters. Cluster 4 stood out as almost all corresponding marker genes were hardly expressed in other four clusters. d Top 20 marker genes distinguishing cluster 0 from 1 (left) and cluster 2 from 3 (right) showed a strong overlap. Twelve marker genes were conserved in top 20 most significant marker genes for both pairs of comparisons