TABLE 2.

Direct PCs–behavior^a relationships and mediation analyses of the detected brain functional connections

	Cognitive composite				Mediation		Language composite				Mediation		Motor composite				Mediation
	e	SE	t	p	DRUG	NONDRUG	e	SE	t	p	DRUG	NONDRUG	e	SE	t	p	DRUG	NONDRUG
Birth age	0.00	0.02	0.08	.936			0.01	0.02	0.57	.568			0.13	0.03	4.53	.000	0.023	0.575
Sex	0.03	0.28	0.11	.915			−0.17	0.20	−0.84	.401			−0.24	0.31	−0.78	.436
Birth weight	−0.27	0.23	−1.18	.241			−0.28	0.17	−1.66	.100			0.25	0.26	0.97	.336
EPDS	0.19	0.06	3.33	.001	0.008	0.019	0.02	0.04	0.42	.679			0.06	0.07	0.86	.392
Cocaine	0.67	0.32	2.06	.042	0.806	0.028	0.02	0.23	0.07	.944			2.05	0.36	5.61	.000	0.000	0.000
Nicotine	0.37	0.29	1.30	.198			0.76	0.21	3.69	.000	0.127	0.001	1.20	0.32	3.71	.000	0.000	0.000
Alcohol	−0.33	0.42	−0.80	.425			−0.04	0.30	−0.12	.906			−0.45	0.47	−0.96	.338
Marijuana	0.10	0.38	0.27	.786			−0.40	0.27	−1.48	0.142			−0.34	0.43	−0.79	0.434
SSRIs	2.35	0.69	3.42	.001	0.270	0.005	1.47	0.50	2.94	.004	0.106	0.006	3.66	0.79	4.65	.000	0.409	0.000
Opiates	0.38	0.58	0.66	.509			–0.23	0.42	−0.54	.588			−0.15	0.66	−0.22	.823

Note: Bold p values indicate significance (FDR corrected, q = 0.05).

Abbreviations: CTR, drug‐free control infants; E, estimate; EPDS, Edinburgh Postnatal Depression Scale; FDR, false discovery rate; PDE, prenatal drug exposure; SSRI, selective serotonin reuptake inhibitor.

^aBayley Scales of Infant and Toddler Development III.