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Comparison of Selective Pressure among the Subcircuits
| No. Gene with Significant Shifts in Strength of Purifying Selection |
|||
|---|---|---|---|
| Subcircuits | No. gene | Intensified (%) | Relaxed (%) |
| Core | 11 | 4 (36.4) | 1 (9) |
| JAK–STAT | 17 | 9 (52.9) | 0 |
| MAPK | 26 | 8 (30.8) | 1 (3.8) |
| OSNa activated | 15 | 4 (26.7) | 3 (20) |
| OSNa suppressed | 18 | 9 (50) | 0 |
| PI3K–Akt | 29 | 13 (44.8) | 0 |
| TGFβ | 27 | 9 (33.3) | 2 (7.4) |
| Wnt | 40 | 16 (40) | 4 (10) |
OCT4 (POU5F1), SOX2, and NANOG.
