Table 3.
Effect of the LPS and/or BA injection on the neurotransmitter concentrations in plasma and brain
Parameters | Groups | Brain | Plasma | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Tyr | Trp | GABA | Ach | DA | 5-HT | KA | Tyr | Trp | GABA | ||
Neurotransmitter concentrations (μmol/L) | C | 530 | 267 | 8,320 | 12.9 | 91.0 | 0.15 | 0.31 | 134 | 11.4 | 0.36 |
B | 605 | 234 | 8,070 | 8.7 | 87.6 | 0.15 | 0.35 | 210 | 10.2 | 0.36 | |
L | 485 | 224 | 7,980 | 21.4 | 101.9 | 0.16 | 0.32 | 113 | 12.9 | 0.35 | |
BL | 514 | 235 | 7,991 | 20.7 | 100.2 | 0.16 | 0.32 | 137 | 10.3 | 0.42 | |
pooled SE | 22 | 9 | 103 | 2.1 | 5.2 | 0.01 | 0.01 | 12 | 1.1 | 0.05 | |
Randomized block design 2-way ANOVA p value | Repeat | 0.04 | 0.78 | 0.71 | 0.003 | <0.001 | 0.001 | 0.31 | <0.001 | 0.99 | <0.001 |
LPS | 0.10 | 0.23 | 0.26 | 0.01 | 0.24 | 0.45 | 0.71 | 0.02 | 0.75 | 0.67 | |
BA | 0.66 | 0.75 | 0.21 | 0.67 | 0.93 | 0.85 | 0.41 | 0.007 | 0.41 | 0.39 | |
Interaction | 0.23 | 0.68 | 0.39 | 0.82 | 0.7 | 0.56 | 0.46 | 0.07 | 0.76 | 0.45 |
No concentration of 3-Hydroxy kynurenine or adrenaline was detected in the samples
The concentrations of Ach, DA, 5-HT and KA in blood plasma were too low to be detected by the analysis
CO control group, BA Butyrate group, LP Lipopolysaccharide group, BL Butyrate and lipopolysaccharide group, Tyr tyrosine, Trp tryptophan Trp, GABA gamma amino butyric acid, ACh acetylcholine, DA dopamine, 5-HT serotonin, KA kynurenic acid