Skip to main content
. 2020 Nov 5;17:331. doi: 10.1186/s12974-020-02008-8

Table 3.

Effect of the LPS and/or BA injection on the neurotransmitter concentrations in plasma and brain

Parameters Groups Brain Plasma
Tyr Trp GABA Ach DA 5-HT KA Tyr Trp GABA
Neurotransmitter concentrations (μmol/L) C 530 267 8,320 12.9 91.0 0.15 0.31 134 11.4 0.36
B 605 234 8,070 8.7 87.6 0.15 0.35 210 10.2 0.36
L 485 224 7,980 21.4 101.9 0.16 0.32 113 12.9 0.35
BL 514 235 7,991 20.7 100.2 0.16 0.32 137 10.3 0.42
pooled SE 22 9 103 2.1 5.2 0.01 0.01 12 1.1 0.05
Randomized block design 2-way ANOVA p value Repeat 0.04 0.78 0.71 0.003 <0.001 0.001 0.31 <0.001 0.99 <0.001
LPS 0.10 0.23 0.26 0.01 0.24 0.45 0.71 0.02 0.75 0.67
BA 0.66 0.75 0.21 0.67 0.93 0.85 0.41 0.007 0.41 0.39
Interaction 0.23 0.68 0.39 0.82 0.7 0.56 0.46 0.07 0.76 0.45

No concentration of 3-Hydroxy kynurenine or adrenaline was detected in the samples

The concentrations of Ach, DA, 5-HT and KA in blood plasma were too low to be detected by the analysis

CO control group, BA Butyrate group, LP Lipopolysaccharide group, BL Butyrate and lipopolysaccharide group, Tyr tyrosine, Trp tryptophan Trp, GABA gamma amino butyric acid, ACh acetylcholine, DA dopamine, 5-HT serotonin, KA kynurenic acid