Table 3.
Multivariable analysis for progression-free survival.
| Univariate |
Multivariable |
|||||
|---|---|---|---|---|---|---|
| No. | 5-yr (%) | HR (95%CI) | P-Value | HR (95%CI) | P-Value | |
| Age (per unit) | 798 | 1.02 (1.01–1.03) | <0.001 | |||
| Ethnicity | 0.001 | |||||
| Caucasian | 65 | 64.6% | 1 | |||
| Black | 50 | 39.8% | 2.10 (1.13–3.91) | |||
| Hispanic | 575 | 63.8% | 0.91 (0.55–1.49) | |||
| Asian | 104 | 54.9% | 1.36 (0.76–2.44) | |||
| Laboratory results | ||||||
| WBC (per unit) | 798 | 1.07 (1.03–1.10) | <0.001 | |||
| Platelet (per unit) | 798 | 1.00 (1.00–1.01) | <0.001 | |||
| Hemoglobin (per unit) | 798 | 0.80 (0.77–0.84) | <0.001 | |||
| BUN (per unit) | 798 | 1.02 (1.01–1.03) | <0.001 | 1.01 (1.00–1.02) | 0.002 | |
| Creatinine (per unit) | 798 | 1.18 (1.12–1.25) | <0.001 | |||
| HCO3 (per unit) | 798 | 0.92 (0.88–0.96) | <0.001 | |||
| Albumin (per unit) | 798 | 0.35 (0.28–0.43) | <0.001 | 0.66 (0.51–0.86) | 0.002 | |
| Histology | 0.047 | |||||
| Squamous cell | 605 | 60.6% | 1 | |||
| Adenocarcinoma | 138 | 66.9% | 0.83 (0.58–1.18) | |||
| Adenosquamous | 32 | 61.6% | 0.92 (0.47–1.80) | |||
| Other | 23 | 47.4% | 2.07 (1.15–3.71) | |||
| Stage | <0.001 | |||||
| Early stage | 290 | 90.5% | 1 | 1 | ||
| Locally-advanced stage | 444 | 51.1% | 6.87 (4.36–10.8) | 6.62 (3.36–13.0) | <0.001 | |
| Distant metastasis | 58 | 42.5% | 39.4 (23.5–66.2) | 22.0 (10.9–44.4) | <0.001 | |
| Primary hysterectomy | <0.001 | |||||
| No | 576 | 49.7% | 1 | 1 | ||
| Yes | 222 | 89.6% | 0.15 (0.09–0.24) | 0.36 (0.19–0.68) | 0.002 | |
| WPRT | 0.002 | |||||
| No | 316 | 75.5% | 1 | 1 | ||
| Yes | 482 | 54.8% | 1.57 (1.17–2.10) | 0.26 (0.17–0.39) | <0.001 | |
| Systemic chemotherapy | <0.001 | |||||
| No | 718 | 67.4% | 1 | |||
| Yes | 80 | 18.0% | 4.70 (3.51–6.28) | |||
| VTE | <0.001 | |||||
| No | 700 | 68.7% | 1 | 1 | ||
| Yes | 98 | 22.3% | 3.24 (2.45–4.29) | 1.95 (1.43–2.67) | <0.001 | |
Log-rank test for univariable analysis (among all covariates tested in Table 1, only significant covariates are listed). A Cox proportional hazard regression model for multivariable analysis (conditional backward method). Significant P-values are emboldened. Abbreviations: HR, Hazard ratio; 95%CI, 95% confidence interval; 5-yr (%), 5-year proportion; WBC, white blood cell; BUN, Blood urea nitrogen; HCO3, bicarbonate; VTE, venous thromboembolism; and WPRT, whole pelvic radiation therapy.