Table 4.

Multivariable analysis for disease-specific overall survival.

			Univariate		Multivariable
	No.	5-yr (%)	HR (95%CI)	P-Value	HR (95%CI)	P-Value
Ethnicity				0.006
Caucasian	65	92.4%	1
Black	50	56.8%	3.00 (1.02–8.78)
Hispanic	575	86.8%	0.88 (0.35–2.20)
Asian	104	82.6%	1.15 (0.39–3.45)
Cigarette use				0.009
No	661	87.4%	1
Yes	114	69.2%	2.07 (1.19–3.61)
Laboratory results
WBC (per unit)	798		1.10 (1.04–1.17)	0.001
Platelet (per unit)	798		1.00 (1.00–1.01)	<0.001	1.00 (1.00–1.01)	0.039
Hemoglobin (per unit)	798		0.83 (0.75–0.91)	0.001
BUN (per unit)	798		1.02 (1.01–1.03)	0.008
Creatinine (per unit)	798		1.16 (1.03–1.30)	0.014
Albumin (per unit)	798		0.32 (0.21–0.47)	<0.001	0.46 (0.29–0.72)	0.001
Histology				0.001
Squamous cell	605	83.6%	1		1
Adenocarcinoma	138	93.6%	0.39 (0.17–0.91)		0.37 (0.16–0.87)	0.023
Adenosquamous	32	86.9%	0.63 (0.16–2.59)		0.87 (0.21–3.62)	0.85
Other	23	67.3%	3.14 (1.35–7.27)		3.37 (1.37–8.27)	0.008
Stage				<0.001
Early stage	290	96.8%	1		1
Locally-advanced stage	444	80.8%	5.09 (2.41–10.8)		1.25 (0.46–3.44)	0.66
Distant metastasis	58	25.2%	37.1 (15.6–88.3)		5.12 (1.60–16.4)	0.006
Primary hysterectomy				<0.001
No	576	78.7%	1		1
Yes	222	98.0%	0.13 (0.05–0.33)		0.22 (0.06–0.77)	0.018
Systemic chemotherapy				<0.001
No	718	89.1%	1
Yes	80	46.3%	6.90 (4.23–11.3)
VTE				<0.001
No	700	90.0%	1		1
Yes	98	55.1%	4.65 (2.90–7.45)		3.54 (2.04–6.13)	<0.001

Log-rank test for univariable analysis (among all covariates tested in Table 1, only significant covariates are listed). A Cox proportional hazard regression model for multivariable analysis (conditional backward method). Significant P-values are emboldened. Abbreviations: HR, Hazard ratio; 95%CI, 95% confidence interval; 5-yr (%), 5-year proportion WBC, white blood cell; BUN, Blood urea nitrogen; and VTE, venous thromboembolism.