. 2020 Nov 5;39:234. doi: 10.1186/s13046-020-01742-4

Table 2.

Correlation between NOX4 expression in tumor stroma and clinicopathological parameters in patients with gallbladder cancer

Variable	NOX4 expression [n (%)]		x² value (P)	Spearman rank correlation, r (P)
Variable	Low	High	x² value (P)	Spearman rank correlation, r (P)
Age (y)
> 65	11 (34.3)	21 (65.7)	0.014 (0.885)	0.010 (0.886)
≤ 65	19 (35.8)	34 (64.2)	0.014 (0.885)	0.010 (0.886)
Gender
Male	18 (33.3)	27 (66.7) 28 (70)	0.006 (0.958)	0.009 (0.960)
Female	12 (30)		0.006 (0.958)	0.009 (0.960)
Tumor location
Bottom	14 (30.4)	32 (69.6)	1.651 (0.350)	0.055 (0.605)
Neck and other	16 (41)	23 (59)	1.651 (0.350)	0.055 (0.605)
Tumor size (cm)
> 3	20 (41.3)	26 (58.7)	2.889 (0.077)	0.325 (0.434)
≤ 3	10 (25.6)	29 (74.4)	2.889 (0.077)	0.325 (0.434)
Histological types
Adenocarcinoma	29 (37)	52 (63)	0.024 (0.922)	0.027 (0.755)
Other^a	1 (33.3)	3 (66.7)	0.024 (0.922)	0.027 (0.755)
Differentiation degree
High	10 (68.7)	6 (31.3)	9.725 (0.009) ^b	0.518 (0.001) ^b
Moderate	12 (44.4)	15 (55.6)
Poor	8 (19)	34 (81)
Liver metastases
(+)	9 (22.5)	31 (77.5)	5.691 (0.022) ^b	0.324 (0.028) ^b
(−)	21 (48.8)	24 (51.2)	5.691 (0.022) ^b	0.324 (0.028) ^b
Vascular invasion
(+)	17 (25.3)	50 (74.7)	8.678 (0.005) ^b	0.462 (0.002) ^b
(−)	13 (55.5)	5 (44.5)	8.678 (0.005) ^b	0.462 (0.002) ^b
Lymph node metastasis
(+)	18 (38.2)	29 (61.8)	0.021 (0.930)	0.026 (0.735)
(−)	12 (36.8)	26 (63.2)	0.021 (0.930)	0.026 (0.735)
Nevin staging
III, IV, V	19 (28.3)	48 (71.7)	4.433 (0.038) ^b	0.322 (0.035) ^b
I, II	11 (55.6)	7 (44.4)	4.433 (0.038) ^b	0.322 (0.035) ^b
Resection method
R1, R2	13 (31.7)	28 (68.3)	0.319 (0.572)	0.025 (0.768)
R0	17 (40.9)	27 (59.1)	0.319 (0.572)	0.025 (0.768)
VM
(+)	15 (68.2)	7 (31.8)	6.113 (0.020) ^b	0.389 (0.021) ^b
(−)	15 (23.8)	48 (76.2)	6.113 (0.020) ^b	0.389 (0.021) ^b

^asquamous cell carcinoma, adenosquamous carcinoma; ^bP < 0.05: statistically significant