TABLE 1.
Demographics of patients with rhabdomyosarcoma and bone marrow metastasis at diagnosis (N = 27)
N | Percentage | |
---|---|---|
Gender | ||
Female | 14 | 52 |
Male | 13 | 48 |
Age | ||
Age <10 years | 6 | 22 |
Age ≥10 years | 21 | 78 |
Subtype | ||
Alveolar | 25 | 93 |
PAX3-FOXO1 fusion | 22 | |
PAX7-FOXO1 fusion | 1 | |
Negative for FOXO1 fusion | 1 | |
Unknown fusion status | 1 | |
Embryonal | 2 | 7 |
Primary site of disease | ||
Extremity/gluteal | 14 | 52 |
Trunk/mediastinum/paravertebral | 4 | 15 |
Abdomen/retroperitoneum | 2 | 7 |
Genitourinary (vulvar/paratesticular) | 2 | 7 |
Parameningeal | 2 | 7 |
Perineal/pelvis | 2 | 7 |
Prostate | 1 | 4 |
Metastatic sites | ||
Bone marrow + bone | 2 | 7 |
Bone marrow + lymph node | 2 | 7 |
≥3 sites including bone marrow | 23 | 85 |
Oberlin score | ||
2 | 2 | 7 |
3 | 11 | 41 |
4 | 14 | 52 |
Note: Alveolar fusion status indicates fusion presence in bone marrow and/or tumor at diagnosis. The Oberlin score was a point system with a maximal score of 4.6