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. 2020 Nov 5;21:272. doi: 10.1186/s13059-020-02183-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Hi-C reveals condensin-dependent chromatin interactions. a Hi-C difference map of the chromosome I left arm comparing cut14⁺ and cut14^SO cells, as well as virtual 4C plots around the indicated viewpoint. Solid lines and shaded areas represent Loess-smoothed Hi-C contacts and 95% confidence intervals, respectively. b Contact probability as a function of genomic distance along the chromosome I left arm in cut14⁺ and cut14^SO cells. c Aggregate Hi-C matrices of high z-score interactions in the indicated conditions. All, all interactions identified in either cut14⁺ or cut14^SO cells; specific, interactions seen only in one of the two conditions; common, interactions identified in both conditions. Numbers of interactions are shown in brackets. d Genomic distances of high z-score interactions plotted as boxplots. ***p = 0.0002