Table 3.
Timing of cholecystectomy in people with ACC
| Study name | Timing of surgery in early group | Number of participants in early group | Timing of surgery in intermediate or delayed group | Number of participants in intermediate or delayed group | Risk of biasa |
|---|---|---|---|---|---|
| Davila 1999 (1) | < 4 days after diagnosis | 27 | 2 months after discharge | 36 | Unclear |
| Gul 2013 (2) | < 72 h after hospital admission | 30 | 6 to 12 weeks after initial conservative treatment | 30 | High |
| Gutt 2013 (3) | < 24 h after hospital admission | 304 | 7 to 45 days after hospital admission2 | 314 | Low |
| Johansson 2003 (4) | < 7 days of diagnosis | 74 | 6 to 8 weeks after discharge | 71 | Low |
| Kolla 2004 (5) | < 24 h after randomisation | 20 | 6 to 12 weeks after the acute episode subsides | 20 | Low |
| Lai 1998 (6) | < 24 h after randomisation | 53 | 6 to 8 weeks after the acute episode subsides | 51 | Low |
| Lo 1998 (7) | < 72 h after admission | 45 | 8 to 12 weeks after discharge | 41 | High |
| Macafee 2009 (8) | < 72 h after recruitment | Not stated | 3 months after discharge | Not stated | High |
| Mustafa 2016 (9) | < 48 to 72 h of diagnosis | 105 | 6 to 12 weeks after initial attack | 105 | High |
| Ozkardes 2014 (10) | < 24 h of admission | 30 | 6 to 8 weeks after initial treatment | 30 | High |
| Rajcok 2016 (11) | < 72 h after occurrence of symptoms | 32 | 6 to 8 weeks after acute cholecystitis | 32 | High |
| Roulin 2016 (12) | During day as soon as possible | 42 | 6 weeks after initial diagnosis | 44 | High |
| Saber 2014 (13) | < 72 h of duration of symptoms | 60 | 6 to 8 weeks from onset of symptoms | 60 | High |
| Verma 2013 (14) | < 72 h of admission | 30 | 6 to 8 weeks from onset of symptoms | 30 | High |
| Yadav 2009 (15) | As soon as possible | 25 | 6 to 8 weeks after discharge | 25 | High |
| Zahur 2014 (16) | < 24 to 48 h after hospital admission | 47 | 6 to 8 weeks after initial conservative treatment | 41 | High |
Main reasons for unclear or high risk of bias
High risk of bias: at least one of random sequence generation, allocation concealment, missing outcome bias or selective outcome reporting bias was classified as high risk of bias
Unclear risk of bias: at least one of random sequence generation, allocation concealment, missing outcome bias or selective outcome reporting bias was classified as unclear risk of bias without any of the domains being classified as high risk of bias
aAll studies were at high risk of bias due to lack of blinding. The risk of bias classification stated here is for the remaining domains
bThis was the only study in which intermediate laparoscopic cholecystectomy was performed; delayed laparoscopic cholecystectomy was performed in the remaining studies