Table 3.
One-year persistence with prophylactic migraine treatment
| Total | Antiserotonin agents | Antidepressants | Beta-blockers | Antiepileptics | Other anticonvulsants | P value | |
| N=599* (100%) | N=123 (20.5%) | N=110 (18.4%) | N=51 (8.5%) | N=132 (22.0%) | N=183 (30.6%) | ||
| Persistent patients† | 157 (26.2) | 17 (13.8) | 24 (21.8) | 16 (31.4) | 30 (22.7) | 70 (38.3) | <0.001 |
| Non-peristent patients† | 442 (73.8) | 106 (86.2) | 86 (78.2) | 35 (68.6) | 102 (77.3) | 113 (61.7) | <0.001 |
| Full discontinuer‡ | 205 (46.4) | 42 (39.6) | 43 (50.0) | 12 (34.3) | 46 (45.1) | 62 (54.9) | |
| Restarting‡ | 137 (31.0) | 19 (17.9) | 24 (27.9) | 18 (51.4) | 36 (35.3) | 40 (35.4) | |
| Switch‡ | 100 (22.6) | 45 (42.5) | 19 (22.1) | 5 (14.3) | 20 (19.6) | 11 (9.7) | |
| Days on treatment before stopping (discontinuation), median (IQR) | 103.0 (89.0) | 110.0 (79.0) | 97.0 (120.0) | 93.0 (78.5) | 90.5 (71.0) | 108.5 (87.0) | |
| Days after treatment interruption before restarting, median (IQR) | 46.0 (60.0) | 39.0 (109.0) | 59.5 (83.0) | 65.0 (64.0) | 26.5 (32.0) | 50.0 (66.0) | |
| Days on treatment before stopping (switching), median (IQR) | 98.0 (57.5) | 91.0 (42.0) | 102.0 (44.0) | 87.0 (57.0) | 134.0 (76.0) | 87.0 (60.0) |
*Number of patients with prophylactic treatment is higher than that reported in table 2 as some patients who started treatment with both acute and prophylactic medications, later continued their treatment only with prophylactic medication.
†The percentage was calculated on the total of treated patients.
‡The percentage was calculated on the total of non-persistent patients.