Figure 1. Beta diversity between AQP4+ and healthy controls.
(A) 3D principal component analysis (PCoA) of weighted UniFrac distances of 16S rRNA genes showing significant beta diversity between AQP4+ patients (green) and healthy controls (red). (B) Results of pairwise PERMANOVA analysis showing a significant difference in beta diversity (p < 0.001, pairwise PERMANOVA test) between patients with AQP4-IgG+ NMOSD and healthy controls. NMOSD = neuromyelitis optica spectrum disorder.