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. 2020 May 6;176(1):124–136. doi: 10.1093/toxsci/kfaa049

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Figure 4. — Effects of 7-day pravastatin and cerivastatin application on myobundle biomarker release. Cumulative biomarker release profiles and quantifications of total release normalized to drug-free control during 7 days of pravastatin or cerivastatin application, shown for (A, B) CK, (C, D) LDH, (E, F) CKm, (G, H) Fabp3, (I, J) sTnI, and (K, L) cTnT. Quantifications performed from n = 8 myobundles per donor, n = 2 technical replicates from N = 2 donors. *p < .01 from CTL and ^#p < .05 from C10. CTL, drug-free control; P50, 250 nM pravastatin; P250, 250 nM pravastatin; C10, 10 nM cerivastatin; C100, 100 nM cerivastatin.