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. 2020 May 6;176(1):124–136. doi: 10.1093/toxsci/kfaa049

Figure 5.

Figure 5.

Effects of 7-day IGF-1 and dexamethasone treatment on myotube diameter and contractile function. A, Representative images of myobundle cross-sections stained for β-spectrin. B, Quantification of myotube diameter from β-spectrin stainings normalized to drug-free control (n = 200 myotubes from 8 myobundles per group from N = 2 donors). C, Representative force traces during twitch and tetanic contraction. D, Quantification of specific force during tetanic contraction normalized to drug-free control (n = 8 myobundles from N = 2 donors). *p < .01 from CTL. CTL, drug-free control. IGF 0.1, 0.1 mg/ml IGF-1; IGF 0.5, 0.5 mg/ml IGF-1; Dex 1, 1 μM dexamethasone; Dex 25, 25 μM dexamethasone.