Table 1. Quantitative synthesis of individual case-control study mortality data.

Study	TCZ mortality	Controls	Odds ratio	95% CI	Weight % (random effects)	p Value
Klopfenstein et al. (2020)	4/20 (20%)	12/25 (48%)	0.271	[0.0704–1.042]	3.54	0.0575
Campochiaro et al. (2020)	5/32 (15.6%)	11/33 (33.3%)	0.37	[0.112–1.227]	4.23	0.104
Capra et al. (2020)	2/62 (3.2%)	11/23 (47.8%)	0.0364	[0.00713–0.185]	2.61	0.0001
Colaneri et al. (2020)	5/21 (23.8%)	6/21 (28.6%)	0.781	[0.197–3.106]	3.41	0.726
Rojas-Marte et al. (2020)	50/96 (52.1%)	60/97 (61.9%)	0.67	[0.378–1.189]	9.7	0.171
Wadud et al. (2020)	17/44 (38.6%)	26/50 (52%)	0.581	[0.255–1.323]	6.9	0.196
Ip et al. (2020)	62/134 (46.3%)	231/413 (55.9%)	0.678	[0.459–1.003]	12.2	0.0519
Roumier et al. (2020)	3/30 (10%)	9/30 (30%)	0.259	[0.0623–1.079]	3.24	0.0635
Guaraldi et al. (2020)	13/179 (7.3%)	73/365 (20%)	0.309	[0.2166–0.574]	9.11	0.0002
Patel et al. (2020)	11/42 (26.2%)	11/41 (28.6%)	0.968	[0.355–2.565]	5.62	0.947
Eimer et al. (2020)	4/22 (18.2%)	7/22 (31.8%)	0.476	[0.116–1.94]	3.31	0.301
Canziani et al. (2020)	17/64 (26.6%)	24/64 (37.5%)	0.603	[0.285–1.277]	7.61	0.187
Gokhale et al. (2020)	33/70 (47.1%)	61/91 (67%)	0.345	[0.185–0.644]	8.85	0.0008
Rossotti et al. (2020)	20/74 (26.4%)	86/146 (58.9%)	0.517	[0.301–0.887]	9.23	0.0166
Somers et al. (2020)	14/78 (17.9%)	22/76 (35.5%)	0.379	[0.189–0.836]	7.67	0.0151
Potere et al. (2020)	2/40 (5%)	12/40 (30%)	0.123	[0.0254–0.593]	2.76	0.009
Total (random effects)	262/1008 (26.0%)	667/1537 (43.4%)	0.453	[0.376–0.547]	100	<0.001