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. 2020 Sep 30;11:565484. doi: 10.3389/fimmu.2020.565484

FIGURE 1.

FIGURE 1

Effects of IA LPS exposure on chorioamnionitis (CA), changes of plasma proteome, and liver acute gene responses in preterm pigs at birth. (A) Inflammatory cell infiltration in the chorioamnion. (B) Pathway enrichment of differentially regulated proteins in plasma between LPS vs. CON pigs at birth (day 1). Every pathway is labeled according to the color. (C) Differentially regulated protein networks in plasma in LPS vs. CON pigs at birth (list of differential expressed proteins in Supplementary Table 2). (D) Changes of acute response genes in the liver of LPS pigs at birth. n = 10 in both groups. (E) A subgroup of differentially regulated proteins in plasma showed their functions related to kidney injury. The pathway enrichment was performed by GeneMANIA (84). Color code for (E) Blue: pathway interaction; Yellow: shared protein domains; Purple: co-expression; and Red: physical interactions. Width of the edge shows a weighted interaction network where each pair of genes is assigned an association weight (84). Data are presented as mean ± SEM. *, ***p < 0.05 and 0.001, respectively. #p < 0.1.