TABLE 5.

Standardized differences of baseline covariates before and after propensity score matching

Covariate	Before PS matching ‐ means			After PS matching ‐ means
	BRAF/MEKi	aPD‐1	Standardized difference a	BRAF/MEKi	aPD‐1	Standardized difference
Age at 1L initiation	61.118638	62.893807	0.124	61.397791	62.630218	0.055
BMI at 1L initiation	28.160065	28.091854	0.012	27.77051	27.504839	0.030
Deyo‐adapted Charlson Score	1.1574803	1.3209877	0.103	1.0619455	1.2157635	0.074
Brain metastases	0.3700787	0.2098765	0.359	0.3026492	0.282466	0.044
Lung metastases	0.496063	0.2839506	0.446	0.4578971	0.4458166	0.024
Liver metastases	0.3070866	0.0864198	0.578	0.2198274	0.20815	0.028
Bone metastases	0.2992126	0.2098765	0.206	0.3089958	0.3113862	0.005
Other metastases	0.7322835	0.5555556	0.376	0.6873984	0.639114	0.102
ECOG performance status 0‐1	0.5826772	0.7530864	0.368	0.6058463	0.5896688	0.033
ECOG performance status 2+	0.2204724	0.0493827	0.517	0.1523432	0.1494931	0.008
ECOG performance status not documented	0.1968504	0.1975309	0.002	0.2418106	0.2608381	0.044
Stage at diagnosis III/IV	0.8267717	0.6296296	0.454	0.7199062	0.721749	0.004
Stage at diagnosis I/II	0.0866142	0.0740741	0.046	0.0767331	0.0789891	0.008
Stage at diagnosis not documented	0.0866142	0.2962963	0.553	0.2033607	0.1992619	0.010
Albumin result – low	0.3464567	0.1481481	0.472	0.2714096	0.2513166	0.046
Albumin result – normal	0.503937	0.7901235	0.628	0.6100672	0.632766	0.047
Albumin result ‐ not documented	0.1496063	0.0617284	0.289	0.1185232	0.1159174	0.008
Female	0.3543307	0.382716	0.059	0.3917868	0.3827421	0.019
Practice region ‐ South	0.5669291	0.5432099	0.048	0.5134602	0.5636567	0.101
Practice region ‐ West	0.3149606	0.2716049	0.095	0.2924953	0.2746459	0.040
Practice region ‐ Midwest	0.0708661	0.1111111	0.140	0.1267328	0.0757432	0.170
Practice region ‐ Northeast	0.0472441	0.0740741	0.113	0.0673117	0.0859542	0.070
Prior radiation	0.3700787	0.3703704	0.001	0.3939133	0.4177884	0.049
Prior surgery	0.6614173	0.7530864	0.202	0.7084217	0.711024	0.006
LDH result ‐ normal	0.3700787	0.5061728	0.277	0.4089619	0.3629776	0.095
LDH result ‐ elevated	0.2519685	0.1851852	0.162	0.2306331	0.2646264	0.079
LDH result ‐ not documented	0.3779528	0.308642	0.146	0.360405	0.372396	0.025
History of tobacco exposure	0.488189	0.5185185	0.061	0.5264428	0.5011438	0.051
History of tobacco exposure ‐ not documented	0.015748	0.0246914	0.064	0.0144088	0.0162188	0.015

Abbreviations: 1L, first‐line; aPD‐1, anti‐PD‐1 monotherapies; BMI, body mass index; BRAF/MEKi, BRAF/MEK inhibitors; ECOG, Eastern Cooperative Oncology Group; LDH, lactate dehydrogenase.

^aAny standardized difference of more than 0.2 suggests an balanced between the two groups.