LINC00857 accelerates cell proliferation, migration, invasion, and glycolysis but restrains cell apoptosis in ovarian cancer. A, LINC00857 expression in ovarian cancer was tested through quantitative real‐time polymerase chain reaction (qRT‐PCR). B, The qRT‐PCR assay tested the knockdown efficiency of LINC00857 expression in SKOV3 and A2780 cells. C, EdU assay was utilized to evaluated cell proliferation in SKOV3 and A2780 cells which were transfected sh‐LINC00857. D and E, The migration and invasion capabilities of SKOV3 and A2780 cells were measured by transwell assay when LINC00857 was subjected to knockdown. F and G, TUNEL and cytometry assays were conducted to test cell apoptosis after silencing LINC00857. H, The F‐FDG uptake, lactate release, and ATP production level were detected in SKOV3 and A2780 cells. *P < 0.05, **P < 0.01