TABLE 2.
Summary of confidence in estimated effect sizes and therapy ranking
| Comparison | Recurrence | Progression | ||||
|---|---|---|---|---|---|---|
| Evidence type | Confidence | Downgrading reasons | Evidence type | Confidence | Downgrading reasons | |
| BCG versus MMC | Mixed | Very low | Sl; Id; Ic | Mixed | Low | Sl; Ip |
| BCG versus IFN | Mixed | Low | Sl; Ip | Mixed | Low | Sl; Ip |
| BCG versus ADM | Mixed | Low | Sl; Ic | Mixed | Moderate | Sl |
| BCG versus EPI | Mixed | Low | Sl; Ic | Mixed | Moderate | Sl; |
| BCG versus GEM | Mixed | Low | Sl; Ic | Mixed | Low | Sl; Ip |
| BCG versus THP | Mixed | Moderate | Sl; | Mixed | Low | Sl; Ip |
| BCG versus TURBT | Mixed | Moderate | Sl; | Mixed | Moderate | Sl; |
| MMC versus IFN | Mixed | Very low | Sl; Ic; Ip | Mixed | Low | Sl; Ip |
| MMC versus ADM | Mixed | Low | Sl; Id | Mixed | Moderate | Sl; |
| MMC versus EPI | Mixed | Low | Sl; Ip | Mixed | Low | Sl; Ip |
| MMC versus GEM | Mixed | Low | Sl; Ip | Mixed | Low | Sl; Ip |
| MMC versus THP | Mixed | Low | Sl; Ip | Mixed | Low | Sl; Ip |
| MMC versus TURBT | Mixed | Moderate | Sl | Mixed | Low | Sl; Ic |
| IFN versus ADM | Indirect | Low | Sl; Id | Indirect | Low | Sl; Id |
| IFN versus EPI | Indirect | Very low | Sl; Id; Ip | Indirect | Very low | Sl; Id; Ip |
| IFN versus GEM | Indirect | Very low | Sl; Id; Ip | Indirect | Very low | Sl; Id; Ip |
| IFN versus THP | Indirect | Very low | Sl; Id; Ip | Indirect | Very low | Sl; Id; Ip |
| IFN versus TURBT | Mixed | Moderate | Sl; | Mixed | Moderate | Sl; |
| ADM versus EPI | Mixed | Low | Sl; Ip | Mixed | Moderate | Sl; |
| ADM versus GEM | Indirect | Low | Sl; Id; | Indirect | Low | Sl; Id; |
| ADM versus THP | Mixed | Low | Sl; Ip | Mixed | Low | Sl; Ip |
| ADM versus TURBT | Mixed | Very low | Sl; Ic; Pb | Mixed | Low | Sl; Ip |
| EPI versus GEM | Indirect | Low | Sl; Id; | Indirect | Moderate | Sl |
| EPI versus THP | Indirect | Very low | Sl; Id; Ip | Indirect | Low | Sl; Ip |
| EPI versus TURBT | Mixed | Low | Sl; Ic; | Indirect | Low | Sl; Id |
| GEM versus THP | Indirect | Very low | Sl; Id; Ip | Indirect | Very low | Sl; Id; Ip |
| GEM versus TURBT | Indirect | Low | Sl; Id; | Indirect | Low | Sl; Id |
| THP versus TURBT | Mixed | Very low | Sl; Ic; Ip | Indirect | Low | Sl; Ip |
| Therapy ranking | Low | Sl; Ic | Very low | Sl; Id; Ip | ||
Abbreviations: Ic, inconsistency; Id, indirectness; Ip, imprecision; Pb, publication bias; Sl, study limitations.