Table 3.
One‐generation dose range‐finding study in rats (SLI, 2000a)
| Dose (mg Ni/kg bw per day) | 0a | 2.2 | 4.4 | 6.6 | 11 | 17 |
|---|---|---|---|---|---|---|
| Mean post‐implantation loss | 0.4 | 2.6 | 1.5 | 2.3* | 2.7** | 4.8** |
| Number of litters with post‐implantation loss | 2/8 | 5/8 | 6/8 | 6/7 | 7/7 | 8/8 |
| Number of litters with at least three post‐implantations losses | 0/8 | 1/8 | 1/8 | 2/7 | 3/7 | 7/8 |
| Number of dead/live pups, at delivery | 1/128 | 12/100** | 10/106** | 10/92** | 4/89 | 23/80** |
bw: body weight; Ni: nickel.
a
Historical control: mean: 1.5 (0.88–2.31).
*
p < 0.05.
**
p < 0.01.