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. 2019 Oct 30;71(8):1817–1823. doi: 10.1093/cid/ciz1071

Table 2.

Parameters for Final Parametric Survival Model Including Predictive Relations and Estimates of Uncertainty

Parameter Value RSE
BASEa, base hazard, day −1 0.0286 41%
ka, rate constant exponential decline in hazard, day −1 0.0333 17%
θ GCSa, GCS effect −0.256 28%
θ agea, age effect 1.04 39%
θ RIFa, rifampicin EC50, mg/L × h 171 86%

Abbreviations: BASE, base hazard; EC50, exposure giving half of maximal effect; GCS, individual Glasgow Coma Scale score at baseline; RSE, relative standard error.

aParametric hazard model: h(t) = BASE × exp(−k × t) × (1 + θ GCS × [GCS-13]) × (age/30)^θage × (1 – AUCRIF / [θ RIF + AUCRIF]), where AUCRIF is the estimated individual 24-hour area under the concentration curve for rifampicin day 2 ±1 on study.