TABLE 3.
PK Parameters for Plasma d- Plus l-methylphenidate After Administration of PRC-063 as Intact Capsules or as Capsule Contents Sprinkled on Different Foods (Study III)
| Intact Capsules (n = 29) | Apple Sauce (n = 28) | Yoghurt (n = 28) | Ice Cream (n = 28) | |
|---|---|---|---|---|
| AUC0–24, ng · h/mL, mean ± SD (CV) | 219.97 ± 81.46 (37.03%) | 225.03 ± 74.45 (33.09%) | 216.61 ± 67.99 (31.39%) | 219.44 ± 66.76 (30.42%) |
| AUC0–t*, ng · h/mL, mean ± SD (CV) | 248.86 ± 99.52 (39.99%) | 249.38 ± 87.66 (35.15%) | 245.64 ± 84.29 (34.31%) | 248.82 ± 88.25 (35.47%) |
| AUC0–inf, ng · h/mL, mean ± SD (CV) | 255.82 ± 104.90 (41.01%) | 254.17 ± 90.81 (35.73%) | 252.74 ± 90.27 (35.72%) | 258.58 ± 105.33 (40.73%) |
| Cmax, ng/mL, mean ± SD (CV) | 15.74 ± 5.59 (35.48) | 17.38 ± 6.07 (34.93%) | 15.69 ± 4.72 (30.08%) | 16.41 ± 4.63 (28.20%) |
| Tmax, median (range), h | 10.0 (1.0–16.0) | 12.0 (1.0–16.0) | 11.0 (0.5–16.0) | 12.0 (1.0–24.0) |
| T½ el, mean ± SD, h | 4.96 ± 1.15 | 4.48 ± 1.06 | 4.99 ± 1.35 | 4.83 ± 1.62 |
| Residual area†, mean ± SD, % | 2.44 ± 2.05 | 1.74 ± 1.38 | 2.41 ± 2.16 | 2.66 ± 4.27 |
*t = 36 hours.
†36 hours to infinity.