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. 2020 Sep 21;30(6):574–579. doi: 10.1097/CMR.0000000000000694

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Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1 — Insulin-like growth factor type I receptor (IGF-1R) expression and effect of IMC-A12 in UM cells. (a) IGF-1R protein levels in a panel of UM cells. (b) IMC-A12 inhibits IGF-1R activation in UM cells: IMC-A12 dose response in UM cells showing inhibition of IGF-1R phosphorylation on treatment of OCM1 and MEL270 with increasing concentration of the agent. (c) Time course of IMC-A12 mediated IGF-1R inhibition: 50 ug/mL IMC-A12 can completely inhibit IGF-1R phosphorylation post 6 h treatment in vitro. (d) IMC-A12 inhibits IGF-1R dependent signaling in UM cells: A treatment with 50 ug/mL IMC-A12 inhibited Akt and Erk1/2 activation in UM cells post 6 h treatment. (e) IMC-A12 inhibits UM cell migration in an in vitro cell migration assay: 50 ug/mL IMC-A12 inhibited cell migration in 92.1 and OMM1 cells on overnight treatment.