Table 2.

Test results for three-sample FITs requested in primary care in symptomatic patients, stratified for different test brands and related to diagnoses of CRC

Test result	All FIT brands, n= 15 789	Actim Fecal Blood, n= 4232	Analyz FOB, n= 7889	Chemtrue FOB Test, n= 1756	Diaquick FOB, n= 1751	Diaquick FOB or Analyz FOB, n= 161
Colorectal cancer, n	304	79	158	29	38	0
True positive, n	277	77	140	29	31	0
False negative, n	27	2	18	0	7	0
False positive, n	4298	1230	2090	593	352	33
True negative, n	11 187	2923	5641	1134	1361	128
Sensitivity, %	91.1	97.5	88.6	100	81.6	n/a
Specificity, %	72.2	70.4	73.0	65.7	79.5	79.5
PPV (95% CI)	6.1 (5.4 to 6.8)	5.9 (4.6 to 7.2)	6.3 (5.3 to 7.3)	4.7 (3.0 to 6.3)	8.1 (5.4 to 10.8)	n/a
NPV (95% CI)	99.8 (99.7 to 99.8)	99.9 (99.8 to 100)	99.7 (99.5 to 99.8)	100 (99.7 to 100)	99.5 (99.1 to 99.9)	100 (97.2 to 100)
LR+	3.28	3.29	3.28	2.92	3.98	n/a
LR–	0.12	0.04	0.16	0	0.23	n/a

CRC = colorectal cancer. FIT = faecal immunochemical test. LR− = negative likelihood ratio. LR+ = positive likelihood ratio. n/a = not available. NPV = negative predictive value.

PPV = positive predictive value.