Table 4.

All FIT brands: test results for combinations of three-sample FITs, haemoglobin values, and platelet counts in symptomatic patients in primary care related to diagnoses of CRC

Test result	FIT and haemoglobin value, n= 13 863				FIT, haemoglobin value, and platelet count, n= 10 973
	Positive FIT	Anaemiaa	Anaemiaa and positive FIT	Anaemiaa and/or positive FIT	Positive FIT	Thrombocytosisb	Thrombocytosisb and positive FIT	Thrombocytosisb and/or positive FIT	Thrombocytosisb and/or anaemiaa and/or positive FIT
Colorectal cancer, n	289	289	289	289	237	237	237	237	237
True positive, n	262	132	123	271	212	40	39	213	222
False negative, n	27	157	166	18	25	197	198	24	15
False positive, n	3858	3685	1356	6187	3135	875	355	3655	5394
True negative, n	9716	9889	12 218	7387	7601	9861	10 381	7081	5342
Sensitivity, %	90.7	45.7	42.6	93.8	89.5	16.9	16.5	89.9	93.7
Specificity, %	71.6	72.9	90.0	54.4	70.8	91.8	96.7	66.0	49.8
PPV (95% CI)	6.4.	3.5 (2.9 to 4.1)	8.3 (6.9 to 9.7)	4.2 (3.7 to 4.7)	6.3 (5.5 to 7.2)	4.4 (3.0 to 5.7)	9.9 (6.9 to 12.8)	5.5 (4.8 to 6.2)	4.0 (3.5 to 4.5)
NPV (95% CI)	99.7 (99.6 to 99.8)	98.4 (98.2 to 98.7)	98.7 (98.5 to 98.9)	99.8 (99.6 to 99.9)	99.7 (99.5 to 99.8)	98.0 (97.8 to 98.3)	98.1 (97.9 to 98.4)	99.7 (99.5 to 99.8)	99.7 (99.6 to 99.9)
LR+	3.19	1.69	4.26	2.06	3.07	2.06	5.00	2.64	1.87
LR–	0.13	0.74	0.64	0.11	0.15	0.91	0.86	0.15	0.13

^aAnaemia: haemoglobin value< 117 g/l in females, < 134 g/l in males.

^bThrombocytosis: > 387 × 10⁹/l in females and > 348 × 10⁹/l in males in Jämtland Härjedalen, Kronoberg, Västernorrland, Västerbotten; > 390 × 10⁹/l in females and >350x10⁹/l in males in Örebro. CI = confidence interval. CRC = colorectal cancer. FIT = faecal immunochemical test. LR− = negative likelihood ratio. LR+ = positive likelihood ratio. NPV = negative predictive value. PPV = positive predictive value.