Table 2.
Weighted estimates of AKI rate and interaction analysis on the difference scale in cohort B (the primary analysis cohort)
| Antihypertensive Strata | Oxycodone Ratea | NSAID Ratea | NSAID RD within Antihypertensive Strata (95% CI)a |
| Amlodipine | 19.9 | 24.0 | 4.13 (−2.83 to 11.09) |
| RAS | 23.1 | 29.1 | 5.97 (1.88 to 10.07) |
| RAS RD within analgesic strata (95% CI)a | 3.22 (0.29 to 6.14) | 5.06 (−2.46 to 12.60) | Difference in difference: 1.85 (−6.23 to 9.92) |
The difference-in-difference estimate suggests that the effect of NSAIDs on AKI rate does not differ across antihypertensive groups. NSAID, nonsteroidal anti-inflammatory drug; RD, rate difference; RAS, renin-angiotensin system inhibitor.
a
AKI events/1000 person days.