Table 3.
Weighted estimates of AKI rate and interaction analysis on the ratio scale in cohort B (the primary analysis cohort)
| Antihypertensive Strata | Oxycodone Ratea | NSAID Ratea | NSAID RR within Antihypertensive Strata (95% CI) |
| Amlodipine | 19.9 | 24.0 | 1.21 (0.89 to 1.63) |
| RAS | 23.1 | 29.1 | 1.26 (1.09 to 1.45) |
| RAS RR within analgesic strata (95% CI) | 1.16 (1.00 to 1.34) | 1.21 0.89 to 1.63) | Ratio of rate ratios 1.04 (0.74 to 1.45) |
The ratio of rate ratio estimate suggests that the effect of NSAIDs on AKI rate does not differ across antihypertensive groups. NSAID, nonsteroidal anti-inflammatory drug; RR, rate ratio; RAS, renin-angiotensin system inhibitor.
a
AKI events/1000 person days.