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. Author manuscript; available in PMC: 2020 Nov 5.
Published in final edited form as: Nature. 2019 Sep 25;574(7776):112–116. doi: 10.1038/s41586-019-1598-0

Extended Data Fig. 6: Transplantation of dissected PROX1 expressing domain from human organoid and mouse embryo.

Extended Data Fig. 6:

a Dissected PROX1 positive boundary domain at day 13 was transplanted into immunodeficient mouse, and formed duct like structure in the tissue expressing PROX1 and duct marker SOX9 after 1 month. Representative of n = 2 independent transplants showing similar results.

b E9.0 Prox1-GFP mouse embryonic HBP domain was transplanted and formed limited tissue expressing Prox1 (GFP) or Pdx1 at post 7 days of transplantation. Representative of n = 2 independent transplants showing similar results.