Skip to main content
. 2020 Nov 5;17(11):e1003229. doi: 10.1371/journal.pmed.1003229

Fig 2. Visualisation of the overlap of dmCpGs between GDM and the continuous glucose measures.

Fig 2

(A) Venn diagram of the overlap of the dmCpGs (FDR < 0.05) associated with maternal GDM exposure and fasting, 1-h and 2-h PG levels. (B) Venn diagram of the overlap of the DMRs associated with maternal GDM exposure, 1-h and 2-h PG. There were no DMRs associated with fasting glucose levels. (C) RCircos plot showing the distribution in the genome of the top 50 dmCpGs associated with GDM and 1-h PG levels. Track 1 (outer track) shows chromosome number, and track 2 shows the chromosome banding. Track 3 highlights the GDM-associated dmCpGs. Manhattan plots are shown for GDM (track 4) and 1-h PG (track 5) analysis, with dmCpGs FDR < 0.05 shown in red. DMRs associated with GDM (track 6) and 1-h glucose levels (track 7). Overlapping dmCpG names, between GDM and 1-h glucose, shown on the inside, with the innermost track highlighting whether the association between the dmCpGs and GDM are positive (red) or negative (blue). dmCpG, differentially methylated CpG; DMR, differentially methylated region; FDR, false discovery rate; GDM, gestational diabetes mellitus; PG, plasma glucose.