Table 1. Changes in virulence biomarkers in mice infected with twelve clones of Trypanosoma brucei rhodesiense.
| Class | Clone ID | Locality of isolation | Iso. yr | PP passage No | Peak Para. | DPP | MST |
|---|---|---|---|---|---|---|---|
| very-acute | KETRI 2482 | Lumino, Uganda | 1969 | 5±0 7 | 1x106 | 8±0.2 | 9±0.4 |
| KETRI 3304 | Lugala, Uganda | 1971 | 5±0 64 | 7.6x108 | 7.8±0.4 | 9±0.4 | |
| KETRI 3803 | Busia, Kenya | 1961 | 4±0 2 | 9.3x108 | 6.4±0.2 | 8.2±0.3 | |
| Group mean ±SE | 4.7±0.9 | 8.9x108 | 7.4±0.5 | 8.8±0.2 | |||
| Acute | KETRI 2487 | Busoga, Uganda | 1972 | 4±0 5 | 6.2x108 | 7±0 | 18.1±0.7 |
| KETRI 3800 | Busia, Kenya | 2000 | 5.2±0.1 2 | 1.2x108 | 6±0 | 26.0±2.0 | |
| KETRI 3801 | Busia, Kenya | 1989 | 6±0 1 | 6.8x107 | 7.3±0.3 | 20.4±0.8 | |
| Group mean ±SE | 5.03±0.16 | 1.7x108 | 6.7±1.3 | 21.6±1.0 | |||
| Sub-acute | KETRI 3798 | Busia, Kenya | 1989 | 5.3±0.16 2 | 1.6x108 | 9.3±1.7 | 28.2±2.0 |
| KETRI 3926 | Busoga, Uganda | 1972 | 5±0 8 | 1.7x108 | 6.6±0.2 | 38.9±1.6 | |
| Group mean ±SE | 5.2±0.8 | 1.5x108 | 7.9±0.9 | 33.6±1.8 | |||
| Chronic | KETRI 3928 | Tororo, Uganda | 1992 | 6.3±0.3 2 | 7.9x107 | 7.0±0 | 51.8±4.1 |
| KETRI 3664 | Busia, Kenya | 1997 | 6.0±0 2 | 4.8x107 | 7.2±0.3 | 45.6±1.6 | |
| KETRI 3380 | Busoga, Uganda | 2000 | 5.9±0.5 3 | 1.3x108 | 7.3±0.2 | 55.5±2.3 | |
| KETRI 3305 | Lugala, Uganda | 1971 | 6.7±0.2 5 | 3.2x108 | 8.7±0.3 | 46.7±5.1 | |
| Group mean ±SE | 6.3±0.2 | 1.1x108 | 7.5±0.2 | 49.9±1.8 |
Control Non-infected - - - - >60
Key: PP-pre-patent period, Iso Yr–year of isolation, Par-parasitaemia, DPP -days to peak parasitaemia, MST-mean survival times,—No data