Table 2. Results of drug sensitivity evaluation of reference KALRO-BioRI sensitive and resistant T b rhodesiense isolates.
| Sensitive Isolate KETRI 2537 | Resistant isolate KETRI 2538 | |||||
|---|---|---|---|---|---|---|
| Drug | Drug dose (mg/Kg) | Mice cured/5 | Status | Drug dose (mg/Kg) | Mice cured/5 | Status |
| MelB | 40 | 5 | (s) | 40 | 5 | (S) |
| 20 | 4 | (s) | 20 | 0 | (R) | |
| 10 | 5 | (s) | 10 | 0 | (R) | |
| 5 | 5 | (s) | 5 | 0 | (R) | |
| 2.5 | 5 | (s) | 2.5 | 0 | (R) | |
| 1 | 0/5 | (R | 1 | 0 | (R) | |
| diminazene aceturate | 40 | 5 | (s) | 40 | 5 | (S) |
| 20 | 5 | (s) | 20 | 0 | (R) | |
| 10 | 4 | (s) | 10 | 0 | (R) | |
| 5 | 5 | (s) | 5 | 0 | (R) | |
| 2.5 | 5 | (s) | 2.5 | 0 | (R) | |
| 1 | 2 | (R) | 1 | 0 | (R) | |
| Pentamindine | 40 | 5 | (s) | 40 | 5 | (S) |
| 20 | 5 | (s) | 20 | 1 | (R) | |
| 10 | 5 | (s) | 10 | 1 | (R) | |
| 5 | 4 | (s) | 5 | 0 | (R) | |
| 2.5 | 2 | (R) | 2.5 | 0 | (R) | |
| 1 | 0 | (R) | 1 | 0 | (R) | |
| Suramin Control | 40 | 5 | (S) | 40 | 5 | (S) |
| 20 | 5 | (S) | 20 | 5 | (S) | |
| 10 | 5 | (s) | 10 | 5 | (S) | |
| 5 | 5 | (s) | 5 | 5 | (S) | |
| 2.5 | 4 | (s) | 2.5 | 2 | (R) | |
| 1 - |
1 10 |
(R) | 1 - |
0 10 |
(R) | |
Key:- Not treated; The mice groups (n = 5) were treated 24hours post inoculation with the isolates and monitored for 60 days post treatment. An isolate is coded as sensitive (S) when at least 4/5 mice survived for at least 60 days without trypanosome relapse. All other results are coded as resistant (R).