Table 2. Expressions of Ang-2 and its receptors Tie-1 and Tie-2 in primary ovarian cancer and 16 high grade serous tumors with their related metastases.
| Variable | Primary tumors | Primary HGSC | Related metastases | p-value |
|---|---|---|---|---|
| (N = 86) | (N = 16) | HGSC (N = 16) | ||
| Ang-2 | ||||
| IRS (0−12) | 6 (1−12) | 6 (2−6) | 9 (4−12) | 0.001 |
| PP % | 65 (10−90) | 62.5 (25−75) | 82.5(40−98) | 0.001 |
| SI | ||||
| ≤Weak | 21 (24%) | 5 (31%) | 0 (0%) | 0.036* |
| Moderate | 54 (63%) | 9 (56%) | 6 (37.5%) | |
| Strong | 11 (13%) | 2 (13%) | 10 (62.5%) | |
| Stroma SI | ||||
| Weak | 58 (67%) | 10 (63%) | 4 (25%) | 0.145 |
| Strong | 28 (33%) | 6 (37%) | 12 (75%) | |
| Tie-1 | ||||
| IRS (0−12) | 2 (0−12) | 2 (1−6) | 2 (1−6) | 1.000 |
| PP % | 32.5(0−90) | 27.5 (5−70) | 35 (5−70) | 0.789 |
| SI | ||||
| ≤Weak | 74 (86%) | 14 (88%) | 15 (94%) | 0.773 |
| Moderate | 11 (13%) | 2 (12%) | 1 (6%) | |
| Strong | 1 (1%) | 0 (0%) | 0 (0%) | |
| Stroma SI | ||||
| Weak | 37 (43%) | 6 (37%) | 2 (12.5%) | 0.164 |
| Strong | 49 (57%) | 10 (63%) | 14 (87.5%) | |
| Tie-2 | ||||
| IRS (0−12) | 2 (0−12) | 2 (2−8) | 9 (6−12) | 0.002 |
| PP % | 35 (0−90) | 30 (15–85) | 85 (65−98) | 0.001 |
| SI | ||||
| ≤Weak | 54 (64%) | 11 (69%) | 0 (0%) | 0.803 |
| Moderate | 28 (33%) | 5 (31%) | 7 (44%) | |
| Strong | 3 (3%) | 0 (0%) | 9 (56%) | |
| Stroma SI | ||||
| Weak | 50 (59%) | 6 (37%) | 0 (0%) | no statistics** |
| Strong | 35 (41%) | 10 (63%) | 16 (100%) |
IRS and PP are presented as median values (range), SI is presented as N (%). IRS immunoreactive score, PP percentage of positively stained epithelial cells, SI staining intensity, HGSC high grade serous cancer. P-values are estimated by Wilcoxon signed-rank test for IRS, PP and Pearson`s chi-square test for SI of the primary and related metastatic tumors.
* 3 cells (75%) have expected count less than 5.
**SI of stroma in metastatic lesions is constant.