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. 2020 Oct 26;16(10):e1008954. doi: 10.1371/journal.ppat.1008954

Fig 7. Impact of therapeutic vaccination and oral TLR-7 stimulation on SIV DNA persistence in CD4+ T cells of SIV-infected, ART-treated infant RMs.

Fig 7

Comparison of frequency of estimated SIV DNA levels in (A) peripheral, (B) LN, and (C) rectal CD4+ T cells before (12 weeks post infection, wpi) and after (62 wpi) therapeutic vaccine regimen in TV+TLR7 and control RMs as determined by PCR. Dashed line represents the limit of detection and open symbols represent values below the limit of detection. Statistical analysis was performed using a two-sided Wilcoxon rank-sum tests (P < 0.05 was considered significant). (D) Association between log reduction of SIV DNA in peripheral CD4+ and LN CD4+ T cells from pre-vaccination to post-vaccination and magnitude of SIV-specific T cells at week 62 prior to ART interruption measured by IFN-γ ELISPOT in TV+TLR7 RMs. Two-sided Spearman rank correlation test was used to determine statistical significance. R value indicates correlation coefficient.