Table 2.
Clinical and laboratory characteristics of severe COVID-19 patients at baseline.
Patient | Age | Gender | Hemoglobin (g/dL) |
White blood cells (x109/L) | Neutrophils (x106/L) | Lymphocytes (x106/L) | Platelets (x109/L) | C-reactive protein (mg/L) | IL-6 (pg/mL) | Ferritin (ng/mL) | Fibrinogen (mg/dL) | D-dimer (ng/mL) | PaO2 (mmHg) | PaCO2 (mmHg) | FiO2 (%) | PaO2:FiO2 | SpO2:FiO2 | Alveolar-arterial O2 gradient (mmHg) | Ventilation (IV = invasive; NIV: non-invasive) |
|
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Reference range | – | – | – | 14−18 | 4000−10000 | 1500−7500 | 500−5000 | 140−400 | <5 | <10 | 8−252 | 200−400 | <500 | – | – | – | – | – | – | – |
Patients treated with tocilizumab | T 1 | 70 | M | 13,6 | 9500 | 8340 | 730 | 390 | 162 | 258,6 | 2478 | 639 | 727 | 119 | 50 | 70 | 170 | 138 | 223 | IV |
T 2 | 70 | M | 11,6 | 13400 | 4770 | 8200 | 149 | 140 | 28,4 | 1090 | 613 | 1435 | 95 | 45 | 60 | 158 | 163 | 192 | IV | |
T 3 | 70 | M | 13,3 | 8620 | 7810 | 510 | 138 | 307 | 57,7 | 1058 | 846 | 28426 | 142 | 34 | 100 | 142 | 99 | 151 | IV | |
T 4 | 78 | F | 13,9 | 7570 | 5600 | 1250 | 287 | 46 | 18,9 | 1013 | 510 | 1076 | 103 | 40 | 80 | 129 | 123 | 216 | NIV | |
T 5 | 85 | F | 8,4 | 8970 | 8390 | 260 | 257 | 151 | 251,3 | 936 | 755 | 1176 | 147 | 43 | 80 | 184 | 124 | 410 | IV | |
T 6 | 85 | M | 11,1 | 11100 | 10260 | 460 | 224 | 78 | 4,4 | 468 | 567 | 68582 | 122 | 63 | 70 | 174 | 140 | 249 | IV | |
T 7 | 65 | M | 13,8 | 4140 | 5900 | 1020 | 214 | 131 | 270,2 | 2831 | 694 | 980 | 179 | 53 | 50 | 358 | 198 | 320 | IV | |
T 8 | 59 | F | 11,3 | 10400 | 8780 | 860 | 533 | 141 | 84,2 | 760 | 755 | 1370 | 108 | 48 | 50 | 216 | 198 | 196 | IV | |
T 9 | 57 | M | 12,9 | 7020 | 5300 | 1180 | 304 | 106 | 8,8 | 1073 | 584 | 467 | 129 | 39 | 80 | 161 | 123 | 96 | NIV | |
T 10 | 73 | M | 11,3 | 6190 | 5140 | 490 | 227 | 393 | 84,8 | 1399 | 933 | 1177 | 127 | 42 | 80 | 159 | 124 | 196 | NIV | |
T 11 | 58 | M | 10,1 | 5510 | 4850 | 350 | 185 | 223 | 32,7 | 700 | 619 | 109 | 83,8 | 37 | 60 | 140 | 162 | 141 | IV | |
T 12 | 58 | M | 13 | 9700 | 8620 | 610 | 298 | 364 | 72,3 | 1369 | 729 | 587 | 69,4 | 29 | 100 | 69 | 94 | 242 | IV | |
T 13 | 75 | M | 11,9 | 6960 | 6090 | 590 | 231 | 186 | 161,4 | 1610 | 918 | 26033 | 182 | 45 | 85 | 214 | 116 | 164 | IV | |
T 14 | 86 | M | 10,6 | 7410 | 6710 | 540 | 79 | 260 | 171,9 | 2740 | 390 | 82917 | 97,4 | 58 | 100 | 97 | 96 | 223 | IV | |
T 15 | 62 | M | 13 | 11000 | 9450 | 1140 | 402 | 166 | 3,5 | 751 | 651 | 899 | 88 | 56 | 55 | 160 | 173 | 192 | IV | |
T 16 | 58 | M | 12,2 | 4780 | 4380 | 240 | 193 | 104 | 21,8 | 3150 | 552 | 977 | 103 | 34 | 50 | 206 | 196 | 151 | NIV | |
T 17 | 64 | M | 12,9 | 11900 | 10460 | 710 | 430 | 264 | 80 | 1518 | 537 | 110200 | 121 | 44 | 100 | 121 | 98 | 216 | IV | |
T 18 | 45 | M | 10,9 | 6730 | 4580 | 1420 | 225 | 69 | 9,4 | 400 | 531 | 265 | 138 | 33 | 80 | 173 | 123 | 410 | NIV | |
T 19 | 77 | M | 13,2 | 8760 | 8050 | 340 | 596 | 22 | 94,2 | 1385 | 285 | 940 | 87,3 | 46 | 60 | 146 | 162 | 249 | IV | |
T 20 | 72 | M | 11,2 | 6610 | 6050 | 350 | 122 | 150 | 46,1 | 779 | 548 | 951 | 116 | 38 | 45 | 258 | 216 | 320 | IV | |
Mean | 68 | – | 12 | 8314 | 6977 | 1063 | 274 | 173 | 88 | 1375 | 633 | 16465 | 118 | 44 | 73 | 172 | 143 | 346 | – | |
SD | 11 | – | 1 | 2457 | 1967 | 1716 | 136 | 101 | 87,9 | 807 | 162 | 32282 | 30 | 9 | 18 | 61 | 38 | 136 | – | |
Patients treated with standard-of-care | S 1 | 75 | F | 8,4 | 18800 | 13520 | 1690 | – | 207 | – | 1766 | 390 | – | 96 | 39 | 44 | 217 | 223 | 170 | no |
S 2 | 70 | M | 10 | 26400 | 25400 | 80 | 280 | 335 | 61,1 | 1131 | 881 | 1855 | 90 | 67 | 50 | 180 | 192 | 183 | IV | |
S 3 | 74 | M | 8,9 | 11800 | 10960 | 500 | – | 171 | 35,6 | 2367 | 423 | 64595 | 124 | 48 | 65 | 191 | 151 | 280 | IV | |
S 4 | 68 | M | 14,2 | 8230 | 7350 | 530 | 413 | 78 | 17,3 | 6166 | 523 | 294 | 103 | 41 | 45 | 229 | 216 | 167 | IV | |
S 5 | 72 | F | 9,2 | 7990 | 5200 | 2260 | 265 | 0 | – | 599 | 507 | 1693 | 100 | 40 | 24 | 417 | 410 | 21 | NIV | |
S 6 | 45 | F | 7,2 | 20 | 10 | 10 | 10 | 286 | 200,1 | 3523 | 619 | 4033 | 115 | 29 | 40 | 288 | 249 | 134 | IV | |
S 7 | 80 | M | 12,1 | 9050 | 8222 | 500 | 237 | 110 | 81,9 | 2895 | 563 | 829 | 86 | 36 | 30 | 287 | 320 | 83 | IV | |
S 8 | 60 | M | 7,7 | 12400 | 11420 | 430 | 92 | 107 | – | 4305 | 192 | 11790 | 113 | 54 | 50 | 226 | 196 | 176 | no | |
S 9 | 69 | M | 8,6 | 5600 | 4790 | 470 | 179 | 170 | 143 | 2844 | 601 | 3334 | 106 | 59 | 100 | 106 | 96 | 533 | IV | |
S 10 | 65 | M | 9,7 | 5330 | 4650 | 440 | 188 | 36 | – | 3033 | 452 | 674 | 103 | 51 | 50 | 206 | 196 | 190 | IV | |
S 11 | 58 | F | 11,5 | 11600 | 10520 | 650 | 168 | 267 | 223 | 171 | 390 | 1817 | 130 | 39 | 70 | 186 | 141 | 320 | NIV | |
S 12 | 77 | M | 9 | 4900 | 4030 | 540 | 176 | 118 | 23,4 | 849 | – | 3479 | 93 | 43 | 40 | 231 | 242 | 138 | no | |
S 13 | 73 | M | 10,4 | 8230 | 7490 | 610 | 196 | 103 | 37,8 | 5855 | 659 | 7349 | 121 | 31 | 60 | 202 | 164 | 268 | IV | |
Mean | 68 | – | 10 | 10027 | 8736 | 670 | 200 | 153 | 91 | 2731 | 517 | 8479 | 106 | 44 | 51 | 228 | 215 | 205 | – | |
SD | 9 | – | 2 | 6683 | 6210 | 619 | 104 | 99 | 78 | 1894 | 171 | 17973 | 14 | 11 | 19 | 73 | 81 | 127 | – | |
p value* | 0,957 | – | 0,0005 | 0,302 | 0,244 | 0,436 | 0,128 | 0,576 | 0,921 | 0,008 | 0,104 | 0,439 | 0,243 | 0,0764 | 0,005 | 0,026 | 0,002 | 0,008 | – |
Unpaired two-tailed Student’s t-test.