Table 2.
Sample characteristics by sex and diagnostic group
| Normals N=304 |
aMCI N=515 |
AD dementia N=175 |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Parameters | Females N=158 (52%*) Mean (SD) |
Males N=146 (48%*) Mean (SD) |
p-value | Females N=226 (44%*) Mean (SD) |
Males N=289 (56%*) Mean (SD) |
p-value | Females N=71 (40%*) Mean (SD) |
Males N=104 (60%*) Mean (SD) |
p-value |
| Age | 73.0 (5.6) | 74.6 (6.1) | 0.02 | 70.8 (7.8) | 72.7 (7.3) | 0.005 | 72.3 (7.7) | 75.1 (7.3) | 0.02 |
| Education (years) | 15.9 (2.6) | 17.2 (2.5) | <0.001 | 15.6 (2.6) | 16.5 (2.7) | <0.001 | 15.0 (2.5) | 16.5 (2.5) | <0.001 |
| Race (% Caucasian) | 89.2 | 91.1 | 0.59 | 92.4 | 95.5 | 0.14 | 90.1 | 94.2 | 0.76 |
| APOE4 carrier (%) | 29.1 | 23.3 | 0.25 | 44.7 | 48.1 | 0.44 | 71.8 | 62.5 | 0.20 |
| MMSE score | 29.0 (1.3) | 28.9 (1.3) | 0.62 | 28.1 (1.8) | 28.0 (1.7) | 0.33 | 22.4 (3.1) | 22.9 (2.6) | 0.28 |
| CDR-Sum of Boxes | 0.05 (0.15) | 0.06 (0.24) | 0.46 | 1.4 (0.9) | 1.5 (1.0) | 0.21 | 5.0 (2.0) | 4.8 (2.0) | 0.51 |
| Early aMCI (%) | - | - | - | 57.6 | 58.1 | 0.64 | - | - | - |
| RAVLT immediate recall | 48.1 (9.1) | 43.0 (11.4) | <0.001 | 40.5 (11.7) | 34.1 (9.9) | <0.001 | 22.9 (8.3) | 21.1 (6.6) | 0.11 |
| RAVLT delayed recall | 8.4 (3.7) | 6.8 (4.2) | 0.001 | 5.5 (4.6) | 4.1 (3.6) | <0.001 | 0.4 (0.9) | 0.7 (1.2) | 0.17 |
| Cortical [18F]AV45 SUVR | 1.12 (0.18) | 1.08 (0.16) | 0.04 | 1.20 (0.22) | 1.21 (0.22) | 0.70 | 1.44 (0.16) | 1.33 (0.2) | 0.001 |
Note.
*
The proportion of females to males significantly varies across diagnostic groups, X2=7.83, p=0.02. aMCI = amnestic Mild Cognitive Impairment. AD = Alzheimer’s disease. MMSE = Mini Mental State Exam. RAVLT = Rey Auditory Verbal Learning Test. CDR = Clinical Dementia Rating. SUVR = standardized uptake value ratio.