Table 3.
Results of multivariable linear regression analyses modeling the independent and interactive associations of sex and cortical Aβ burden with verbal memory performance.
| Multivariable Linear Regression Models | ||||||
|---|---|---|---|---|---|---|
| Model 1: No interactions in model | Model 2: Interaction included in model | |||||
| Sample/Outcome | Sex (male vs. female) | Cortical [18F]AV45 SUVR¥ | Sex × cortical [18F]AV45 SUVR¥ | |||
| B, β (SE) | p-value | B, β (SE) | p-value | B, β (SE) | p-value | |
| Overall Sample | ||||||
| Immediate recall | −5.43, −0.21 (0.62) | <0.0001 | −8.71, −0.15 (1.59) | <0.0001 | 5.01, −0.06 (2.68) | 0.06 |
| Delayed recall | −1.28, −0.14 (0.23) | <0.0001 | −3.16, −0.16 (0.59) | <0.0001 | 3.22, −0.12 (0.99) | 0.001 |
| Controls | ||||||
| Immediate recall | −5.45, −0.26 (1.16) | <0.0001 | −2.47, −0.04 (3.44) | 0.47 | −5.61, −0.07 (6.70) | 0.40 |
| Delayed recall | −1.69, −0.21 (0.47) | 0.0003 | −1.02, −0.04 (1.39) | 0.46 | 0.23, −0.01 (2.71) | 0.93 |
| aMCI | ||||||
| Immediate recall | −5.97, −0.26 (0.89) | <0.0001 | −10.74, −0.21 (2.22) | <0.0001 | 5.87, −0.08 (3.96) | 0.14 |
| Delayed recall | −1.33, −0.16 (0.34) | 0.0001 | −4.18, −0.22 (0.85) | <0.0001 | 3.76, −0.14 (1.51) | 0.01 |
| AD Dementia | ||||||
| Immediate recall | −2.82, −0.19 (1.22) | 0.02 | −4.16, −0.12 (2.88) | 0.15 | 5.40, −0.14 (6.19) | 0.38 |
| Delayed recall | 0.11, −0.05 (0.18) | 0.54 | −0.78, −0.15 (0.43) | 0.08 | 0.10, −0.02 (0.94) | 0.91 |
Note. All analyses were adjusted for age, education, ApoE status and diagnostic group (overall sample only). SUVR = standardized uptake value ratio. B = unstandardized regression coefficient. β = standardized regression coefficient. aMCI = amnestic Mild Cognitive Impairment. AD = Alzheimer’s disease.