Table 3.
Vaginal culture results from mice challenged vaginally with C. trachomatis Ser E
| Vaccines | Mice with positive cultures/total (%) | Median no. days to negative culture (range) | No. of positive cultures/total (%) | IFU shed/mouse median (range) |
|---|---|---|---|---|
| rMOMP/SPA08-1 | 16/19 (84)d | 8 (4–15)a | 36/209 (17)b | 413 (0–6,186)a |
| PBS/SPA08-1 | 19/20 (95) | 11 (4–35) | 86/220 (39) | 1,504 (0–21,808) |
| rMOMP/SPA08-3 | 8/10 (80)d | 8 (4–13)a | 20/110 (18)b | 118 (0–1,662)c |
| PBS/SPA08-3 | 10/10 (100) | 13 (11–28) | 41/99 (41) | 180 (100–1,805) |
| rMOMP/SPA08-4 | 20/20 (100)d | 12 (8–42)a | 74/220 (34)b | 235 (2–3,272)a |
| PBS/SPA08-4 | 20/20 (100) | 18 (8–42) | 106/220 (48) | 1,052 (302–5,542) |
| rMOMP/APF | 10/10 (100)d | 15 (11–35)c | 41/110 (37)d | 1,971 (377–76,675)c |
| PBS/APF | 10/10 (100) | 17 (13–35) | 53/110 (48) | 1,281 (428–12,410) |
aP<0.05 by Mann-Whitney U test compared to corresponding PBS control group.
bP<0.05 by Fisher’s exact test compared to corresponding PBS control group.
cP>0.05 by Mann-Whitney U test compared to corresponding PBS control group.
dP>0.05 by Fisher’s exact test compared to corresponding PBS control group.