Table 5.

Clinical trials of reovirus

Therapeutic agent	Cancer type	Phase, study type	Mode of therapy	Purpose of the study	Status	Clinical trial number
Wild-type reovirus	High grade relapsed or refractory brain tumor	Phase 1, open-label, single-group study	Intravenous injection	Dose determination and safety evaluation	Active, not recruiting	NCT02444546
Reolysin in combination with paclitaxel	Recurrent or persistent ovarian epithelial, fallopian tube or primary peritoneal cancer	Phase 2, open-label parallel study	Intravenous administration of reolysin and paclitaxel	Efficacy evaluation of reolysin in combination with paclitaxel	Active, not recruiting	NCT01199263
Reovirus in combination with carfilzomib, dexamethasone and nivolumab	Relapsed or refractory multiple myeloma	Phase 1, open-label, parallel assignment	Intravenous administration of the drugs and the virus	Dose determination of wild-type reovirus	Recruiting	NCT03605719