Figure 5. Interspecies differences in dispersion correlate to interspecies differences in coding constraint.
(A) The number of nonsynonymous polymorphisms scaled to synonymous polymorphisms (Pn/Ps) for each gene was calculated in GTEx human population. Loss-of-function tolerant (LoF intolerant) genes, defined by pLI score (Lek et al., 2016), generally have higher Pn/Ps than loss of function tolerant (LoF tolerant) genes, as shown in ECDF plot. (B) Pn/Ps was calculated for both human and chimpanzee. The distribution of the chimpanzee Pn/Ps to human Pn/Ps ratio is plotted as an ECDF, grouped by whether the gene has higher dispersion estimate in chimpanzee than in human. p-Value indicates a Mann Whitney U-test. Gene-wise Pn/Ps statistics available in Figure 5—source data 1.
Figure 5—source data 1. Gene-wise Pn/Ps statistics for chimpanzee and human.
elife-59929-fig5-data1.txt (1.1MB, txt)