Table 2.

Characteristics of candidate Zika vaccines

NON-REPLICATING	LIVE REPLICATING
● No risk of reversion to virulence	● Risk of reversion to virulence
● No risk of mosquito-competence	● Risk of mosquito-competence
● Variable induction of arms of the immune response	● Induces all arms of immune response
● Usually, multiple doses needed to give protective immunity	● One dose likely gives protective immunity
● Booster doses needed to maintain immunity	● Long-lasting immunity only induced by live vaccine
	● Long-lasting immunity is important if low-level Zika activity intersperses Zika epidemics