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. Author manuscript; available in PMC: 2021 May 10.
Published in final edited form as: AAPS J. 2020 May 10;22(3):70. doi: 10.1208/s12248-020-00451-2

Table II.

Dermis Blood Flow Values (Q) Considered in the Model Analysis

Skin surface temperature, °C Q × 1000 (s−1) Reference
32 0.4a (48)
1.32–9.47 (78)
1.33b (23)
1.8 (49)
2.2 (rat) (32)
3.8–5.5c (79)
1.33 Selected value
42 30–40d (79)
32–43d (23)
43 Selected value
a

Corresponds to 2.4 × 10−2 mL blood/(mL tissue·min). Note that both the exponent and the units are misprinted in (48)

b

Corresponds to 8 mL/(100 mL·min) or a whole body skin blood flow of 250 mL/min

c

Corresponds to a forearm blood flow (skin + muscle) of 4–5 mL/ (min × 100 mL)

d

Corresponds to whole body skin blood flow of 6–8 L/min (~ 60% of cardiac output)