Table 2.
Improvement in oxygenation from baseline to day 15.
| PaO2/FiO2, mmHg | With Eculizumab (N = 35) |
Without Eculizumab (N = 45) |
P-Valuea | ||
|---|---|---|---|---|---|
| Baseline (n = 35) |
Day 15 (n = 28b) |
Baseline (n = 45) |
Day 15 (n = 25c) |
||
| ≤100, n (%) | 13 (37) | 5 (17) | 27 (60) | 10 (40) | 0.08 |
| >100, n (%) | 22 (63) | 24 (83) | 18 (40) | 15 (60) | |
| Shift from ≤100 to >100, n/N (%) | – | 19/29 (66) | – | 4/25 (25) | 0.0003 |
N=number of patients with available data; PaO2/FiO2=ratio of partial pressure of arterial oxygen to fractional inspired oxygen.
a
Fisher's exact test was used to compare the categories of PaO2/FiO2 at day 15 between the two groups.
b
Data missing for 7 patients: 6 patients died and 1 patient left the hospital alive by day 15.
c
Data missing for 20 patients: 17 patients died and 3 patients left the hospital alive by day 15.