Table 6.

Association between disease severity of COVID-19 and laboratory characteristics by multiple regression analysis

Variable	Mild cases (n = 81)		Ordinary cases (n = 486)		Severe and critical cases (n = 31)
	OR(95%CI)	P value	OR(95%CI)	P value	OR(95%CI)	P value
Platelet count (×109/L) (n = 474)	0.997(0.992–1.002)	0.199	0.991(0.986–0.995)	< 0.001	0.979(0.969–0.989)	< 0.001
White blood cell count (×109/L) (n = 503)	0.923(0.779–1.093)	0.351	0.755(0.649–0.879)	< 0.001	0.913(0.725–1.149)	0.437
Lymphocyte count (×109/L) (n = 491)	0.794(0.564–1.118)	0.187	0.383(0.259–0.567)	< 0.001	0.029(0.007–0.114)	< 0.001
Potassium (mmol/L) (n = 418)	0.685(0.351–1.336)	0.267	1.010(0.836–1.221)	0.917	0.283(0.097–0.830)	0.021
Albumin (g/L) (n = 462)	0.953(0.877–1.036)	0.258	0.881(0.820–0.947)	0.001	0.837(0.754–0.930)	0.001
Aspartate aminotransferase (U/L) (n = 390)	0.987(0.933–1.045)	0.657	1.045(1.000–1.093)	0.052	1.071(1.021–1.124)	0.005
Alanine aminotransferase (U/L) (n = 464)	1.008(0.983–1.034)	0.517	1.018(0.996–1.040)	0.109	1.031(1.004–1.058)	0.024
Fibrinogen (g/L) (n = 529)	1.512(0.929–2.460)	0.096	2.514(1.661–3.888)	< 0.001	3.597(2.171–5.960)	< 0.001
Erythrocyte sedimentation rate (mm/h) (n = 326)	1.044(1.005–1.085)	0.028	1.047(1.011–1.084)	0.009	1.086(1.044–1.129)	< 0.001
C-reactive protein (mg/L) (n = 486)	0.882(0.305–2.549)	0.817	0.246(0.103–0.585)	0.002	0.042(0.010–0.186)	< 0.001
CD3 + T lymphocytes (/ul) (n = 123)	1.000(0.999–1.001)	0.777	0.999(0.998–1.000)	0.040	0.995(0.990–0.999)	0.024
CD4 + T lymphocytes (/ul) (n = 123)	0.999(0.997–1.001)	0.382	0.998(0.997–1.000)	0.050	0.994(0.987–1.000)	0.042
CD8 + T lymphocytes (/ul) (n = 123)	1.000(0.998–1.003)	0.717	0.999(0.996–1.001)	0.215	0.998(0.976–1.000)	0.047

CD: cluster of differentiation; OR: odds ratio; CI: confidence interval.