Table 7.
Receiver operating characteristic curve analyses for diagnostic predictor of asymptomatic carriers of COVID-19
| Variables | AUC (95% CI) | P value | Cutoff | Sensitivity | Specificity | Youden index |
|---|---|---|---|---|---|---|
| White blood cell count (×109/L) (n = 503) | 0.715(0.647–0.782) | < 0.001 | 5.015 | 0.811 | 0.571 | 0.382 |
| Lymphocyte count (× 109/L) (n = 491) | 0.740(0.665–0.814) | < 0.001 | 1.365 | 0.784 | 0.598 | 0.382 |
| Eosinophils count (×109/L) (n = 507) | 0.720(0.651–0.789) | < 0.001 | 0.015 | 0.792 | 0.548 | 0.340 |
| Neutrophils count(×109/L) (n = 490) | 0.585(0.506–0.663) | 0.048 | 3.5 | 0.549 | 0.654 | 0.203 |
| Platelet count (×109/L) (n = 474) | 0.696(0.626–0.766) | 0.036 | 190.5 | 0.755 | 0.582 | 0.337 |
| Hemoglobin (g/L) (n = 435) | 0.520(0.434–0.607) | 0.651 | 121.5 | 0.894 | 0.178 | 0.072 |
| Monocytes count (×109/L) (n = 145) | 0.632(0.473–0.790) | 0.147 | 0.365 | 0.818 | 0.5 | 0.318 |
| Potassium (mmol/L) (n = 418) | 0.632(0.545–0.720) | 0.003 | 3.885 | 0.681 | 0.604 | 0.285 |
| Sodium (mmol/L) (n = 419) | 0.648(0.579–0.718) | 0.001 | 139.17 | 0.681 | 0.594 | 0.275 |
| Blood Urea nitrogen (mmol/L) (n = 439) | 0.574(0.498–0.651) | 0.077 | 3.995 | 0.648 | 0.561 | 0.209 |
| Creatinine (umol/L) (n = 481) | 0.425(0.339–0.512) | 0.074 | 15.1 | 0.981 | 0.047 | 0.028 |
| Aspartate aminotransferase (U/L) (n = 390) | 0.358(0.271–0.445) | 0.004 | 13.55 | 1 | 0.028 | 0.028 |
| Total serum bilirubin(umol/L) (n = 487) | 0.481(0.400–0.562) | 0.658 | 5.95 | 0.904 | 0.136 | 0.04 |
| Alanine-aminotransferase (U/L) (n = 464) | 0.449(0.367–0.532) | 0.237 | 6.40 | 1 | 0.007 | 0.007 |
| Alkaline phosphatase (U/L) (n = 464) | 0.695(0.611–0.778) | < 0.001 | 82.70 | 0.569 | 0.797 | 0.366 |
| Albumin (g/L) (n = 462) | 0.692(0.627–0.758) | < 0.001 | 42.65 | 0.846 | 0.52 | 0.366 |
| Lactate dehydrogenase (U/L) (n = 454) | 0.425(0.348–0.501) | 0.082 | 142.00 | 1 | 0.052 | 0.052 |
| Activated partial thromboplastin time (s) (n = 559) | 0.401(0.322–0.481) | 0.015 | 273.00 | 0.018 | 1 | 0.018 |
| Prothrombin time (s) (n = 562) | 0.444(0.378–0.510) | 0.166 | 1.025 | 1 | 0.101 | 0.101 |
| Fibrinogen (g/L) (n = 529) | 0.234(0.173–0.295) | < 0.001 | 1.895 | 1 | 0.025 | 0.025 |
| Procalcitonin (ng/mL) (n = 316) | 0.393(0.287–0.499) | 0.042 | 0.1815 | 0.147 | 0.872 | 0.019 |
| Interleukin-6 (pg/ml) (n = 129) | 0.253(0.143–0.363) | < 0.001 | 4.98 | 0.048 | 0.963 | 0.011 |
| Erythrocyte sedimentation rate (mm/h) (n = 326) | 0.275(0.201–0.349) | < 0.001 | - | - | - | - |
| CD3+ T lymphocytes (/ul) (n = 123) | 0.678(0.545–0.811) | 0.008 | 1416.5 | 0.522 | 0.82 | 0.342 |
| CD4+ T lymphocytes (/ul) (n = 123) | 0.640(0.507–0.773) | 0.036 | 501.0 | 0.783 | 0.53 | 0.313 |
| CD8+ T lymphocytes (/ul) (n = 123) | 0.671(0.550–0.792) | 0.011 | 421.0 | 0.696 | 0.65 | 0.346 |
AUC: area under the curve; CI: confidence interval; CD cluster of differentiation.