Table III.
Nicotine Peak Flux, Delivery Rate (ANOVA Least Squares Mean ± SE, n = 4 Skin Donors, 3–4 Replicates Per Donor) Obtained from Optimization Simulations of 0–24-h 32°C and 42°C In Vitro Permeation Data in Franz Diffusion Cells (Protocols 1 and 2)
| Product | Jmax (μg/(cm2·h)) | Peak delivery ratea (Jmax × A, mg/h) | tmax (h) | |||
|---|---|---|---|---|---|---|
| 42°Cb | 32°Cb | 42°Cc | 32°Cc | 42°Cc | 32°C | |
| TDS-N1 (two-layer TDS) | 270 ± 10 | 161 ± 10 | 6.0 ± 0.2 | 3.6 ± 0.2 | 2.4 ± 0.2 | 2.8 ± 0.2 |
| TDS-N2 (homogeneous TDS) | 121 ± 10 | 60 ± 10 | 3.5 ± 0.2 | 1.7 ± 0.2 | 1.5 ± 0.1 | 2.9 ± 0.1 |
a
21 mg/24 h TDS surface area
b
Products significantly different, p < 0.05
c
Products significantly different, p ≤ 0.001