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. 2020 Nov 30;11(3):e4. doi: 10.5037/jomr.2020.11304

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Copyright © van Oirschot BA, Jansen JA, van de Ven CJ, Geven EJW, Gossen JA. Published in the JOURNAL OF ORAL & MAXILLOFACIAL RESEARCH (http://www.ejomr.org), 30 September 2020.

This is an open-access article, first published in the JOURNAL OF ORAL & MAXILLOFACIAL RESEARCH, distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 UnportedLicense (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work and is properly cited. The copyright, license information and link to the original publication on (http://www.ejomr.org) must be included.

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Histological analysis of bone defects at week 6 (Methylene Blue Basic fuchsin stain, original magnification x400).

A = Histological section of F125 treated defect.

B = High magnification of the boxed area in (A).

C = F125 treated defect showing Bio-Oss^® granules extending into the bone marrow.

D = High magnification of boxed area in (C).

E = F20 treated defect showing remnants of the collagen membrane.

F = High magnification of F50 treated defect showing a void where osteoid tissue and osteoblasts lined the newly formed bone and osteoclast-like cells lined the surface of Bio-Oss^® granules.

Dashed line = defect border; dashed oval = osteon; nb = new bone; cb = cortical bone; bo = Bio-Oss^®; nmt = non-mineralized tissue; closed arrowhead = osteoblasts; bm = bone marrow; ost = osteoid tissue; open arrowhead = osteoclast-like cells.