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. 2020 Oct 15;2020:4850328. doi: 10.1155/2020/4850328

Figure 3.

Figure 3

Pinocembrin protects from myocardial I/R (MI/R) injury in vivo in C57/BL6 mice. Wild-type (WT) mice were subjected to 30 minutes of the left anterior descending coronary artery (LAD) ligation, followed by 24 h of reperfusion, vehicle or pinocembrin intravenously (5 and 10 mg/kg) 5 min before reperfusion. (a) Representative TTC-stained LV transverse slices (scale bar, 1 mm). Areas stained dark blue, white, and red represented nonrisk, infarcted, and ischemic but noninfarcted zones, respectively. (b) Analysis of AAR (% total LV). (c) Analysis of myocardial infarct size (%AAR). (d, e) Plasma LDH activity and cTnI levels. (f) Representative images and analysis of left ventricular EF and FS, n = 9 each. Data represent the mean ± SEM. ∗P < 0.05 versus sham group. #P < 0.05 versus I/R control group.