Table 1.
Clinical and laboratory parameters of PBC patients and healthy controls.
| Feature | Healthy controls (n = 10) | Non-cirrhotic PBC patients (n = 26) | Cirrhotic PBC patients (n = 20) |
|---|---|---|---|
| Age (years) | 53.20 ± 4.13 | 52.12 ± 2.11 | 53.95 ± 2.63 |
| Gender (male) | 4 | 3 | 7 |
| Weight change (kg) | 0.300 ± 0.44 | −0.962 ± 0.51 | −1.50 ± 0.43∗# |
| Weight change (%) | 0.47% ± 0.71% | −1.49% ± 0.77% | −2.71% ± 0.74%∗# |
| >5% within past 6 months | 0 | 2 | 4 |
| BMI (kg/m2) | 23.27 ± 2.51 | 21.39 ± 2.09∗ | 19.82 ± 2.12∗# |
| Low BMI (<18.5 if <70 years) | 0 | 2 | 6 |
| CRP (mg/L) | 3.37 ± 0.49 | 8.89 ± 1.87 | 15.99 ± 1.75∗ |
| CRP > 5 mg/L | 0 | 13∗ | 12∗ |
| Malnutrition (n, %) | 0 | 4 (15.38%) | 9 (45%)∗# |
| GDF15 (pg/mL) | 656.58 ± 146.13 | 3037.41 ± 568.91∗ | 4926.44 ± 662.84∗# |
| ALT (U/L) | 15.80 ± 1.98 | 113.00 ± 17.37∗ | 85.85 ± 15.27∗ |
| AST (U/L) | 21.80 ± 1.29 | 114.12 ± 15.64∗ | 102.10 ± 14.09∗ |
| TBIL (μmol/L) | 8.56 ± 1.34 | 59.85 ± 12.49∗ | 95.69 ± 18.58∗ |
| DBIL (μmol/L) | 2.91 ± 0.56 | 43.71 ± 10.78∗ | 69.87 ± 14.58∗ |
| GGT (U/L) | 25.80 ± 4.62 | 474.08 ± 84.86∗ | 309.60 ± 71.96∗ |
| ALP (U/L) | 60.30 ± 5.66 | 308.08 ± 41.13∗ | 269.95 ± 25.71∗ |
| TBA (μmol/L) | 3.27 ± 0.34 | 81.18 ± 16.80∗ | 132.54 ± 19.57∗# |
| ALB (g/L) | 43.98 ± 0.52 | 38.39 ± 0.85∗ | 34.24 ± 1.02∗# |
| GLB (g/L) | 27.13 ± 1.16 | 34.75 ± 1.28∗ | 35.86 ± 2.25∗ |
| INR | 0.95 ± 0.01 | 1.04 ± 0.06∗ | 1.28 ± 0.09∗# |
| MELD score | N/A | 5.73 ± 1.07 | 10.14 ± 1.47# |
| Mayo risk score | N/A | 5.53 ± 0.29 | 6.58 ± 0.35# |
| ANA positive | 0 | 25 | 19 |
| Anti-SP100 | 0 | 1 | 1 |
| Anti-GP210 | 0 | 1 | 4 |
| AMA positive | 0 | 22 | 16 |
| AMA-M2 positive | 0 | 9 | 6 |
∗ p < 0.05 compared to corresponding values in healthy controls. #p < 0.05 compared to corresponding values in non-cirrhotic PBC patients. PBC: primary biliary cholangitis; BMI: body mass index; GDF15: growth differentiation factor 15; AST: aspartate aminotransferase; ALT: alanine aminotransferase; TBIL: total bilirubin; DBIL: direct bilirubin; GGT: gamma-glutamyl transpeptidase; ALP: alkaline phosphatase; TBA: total bile acids; ALB: albumin; GLB: globulin; INR: international normalized ratio; CRP: C-reactive protein; MELD score: Model for End-stage Liver Disease score.