Table 4.
Clinical and laboratory parameters of biochemical responders and non-responders in cirrhotic PBC patients.
| Feature | Biochemical responders (n = 7) | Biochemical non-responder (n = 13) | p value |
|---|---|---|---|
| Age (years) | 53.29 ± 6.01 | 54.31 ± 2.66 | 0.859 |
| Gender (male) | 3 | 4 | 0.651 |
| GDF15 (pg/mL) | 2983.14 ± 757.12 | 5972.83 ± 809.45 | 0.014 |
| Weight changes (kg) | −0.67 ± 0.33 | −2.00 ± 0.66 | 0.209 |
| ALT (U/L) | 79.29 ± 19.16 | 89.39 ± 21.59 | 0.877 |
| AST (U/L) | 76.71 ± 12.28 | 115.77 ± 19.95 | 0.211 |
| TBIL (μmol/L) | 44.16 ± 22.34 | 123.44 ± 22.87 | 0.003 |
| DBIL (μmol/L) | 31.25 ± 20.68 | 90.66 ± 17.30 | 0.008 |
| GGT (U/L) | 220.43 ± 73.73 | 357.62 ± 102.96 | 0.536 |
| ALP (U/L) | 225.71 ± 40.25 | 293.77 ± 32.23 | 0.249 |
| TBA (μmol/L) | 88.33 ± 27.50 | 156.35 ± 24.38 | 0.097 |
| ALB (g/L) | 36.80 ± 1.47 | 32.87 ± 1.23 | 0.059 |
| GLB (g/L) | 35.10 ± 4.10 | 36.26 ± 2.79 | 0.819 |
| INR | 1.07 ± 0.07 | 1.40 ± 0.13 | 0.040 |
| CRP (mg/L) | 7.20 ± 3.05 | 21.12 ± 5.71 | 0.038 |
| MELD score | 7.36 ± 2.67 | 11.63 ± 1.68 | 0.135 |
| Mayo risk score | 5.23 ± 0.42 | 7.30 ± 0.35 | 0.002 |
PBC: primary biliary cholangitis; GDF15: growth differentiation factor 15; AST: aspartate aminotransferase; ALT: alanine aminotransferase; TBIL: total bilirubin; DBIL: direct bilirubin; GGT: gamma-glutamyl transpeptidase; ALP: alkaline phosphatase; TBA: total bile acids; ALB: albumin; GLB: globulin; INR: international normalized ratio; CRP: C-reactive protein; MELD score: Model for End-stage Liver Disease score.